Diverse diterpenoids from Callicarpa rubella Lindl. as natural inhibitors of macrophage foam cell formation

By: Xue-Wen Wu, Qian-Lang Feng, Yi-Fan Xie, Si-Chen Song, Bin Cheng, Yan Ma, Qing Li, Xu Ji, Xiao-Li Li, Guang Cao, Wei-Lie Xiao

Phytochemistry

DOI：https://doi.org/10.1016/j.phytochem.2023.113748

Published：2023-JUN

Abstract

Ten undescribed diterpenoids namely rubellawus E-N of structural types pimarane (1, 3-4), nor-abietane (2), nor-pimarane (5-6), isopimarane (7-9), and nor-isopimarane (10), along with eleven known compounds, were isolated and identified from the aerial parts of Callicarpa rubella Lindl. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analyses and quantum chemical computations. Pharmacologi-cally, almost all the compounds exhibited a potential inhibitory effect on oxidized low-density lipoprotein -induced macrophage foam cell formation, which suggests that these compounds may be promising candidates in the treatment of atherosclerosis.